Abstract Background The phylum Apicomplexa includes intracellular parasites causing immense global disease burden, the deadliest of them being the human malaria parasite Plasmodium falciparum, which invades and replicates within erythrocytes.The cytoskeletal protein actin is well conserved within apicomplexans but divergent from mammalian actins, a
Expanding the boundary of brand extensions through brand relationship quality
Research on brand extensions identifies the concept of perceived fit as the prime determinant of success.Yet, it is not difficult to find examples of brands that have been extended successfully into “perceptually distant” domains.In an attempt to resolve this discrepancy between research insights and practical experiences, the study Hayward Dec
Analysis for type of 53BP1 nuclear expression by immunofluorescence as an indicator of genomic instability in oropharyngeal squamous epithelial lesions
Abstract A subset of oropharyngeal squamous cell Accessories carcinoma (OPSCC) is caused by the high-risk human papilloma virus (HPV), which expresses p16INK4a immunoreactivity.Dual-color immunofluorescence (IF) analysis of TP53 binding protein-1 (53BP1) and a proliferative indicator, Ki-67, to elucidate genomic instability (GIN) in tumor tissues r
FUT8-AS1 Inhibits the Malignancy of Melanoma Through Promoting miR-145-5p Biogenesis and Suppressing NRAS/MAPK Signaling
Melanoma is the major lethal skin malignancy.However, the critical molecular drivers governing melanoma progression and prognosis are still not clear.By analyzing The Cancer Genome Atlas (TCGA) data, we identified FUT8-AS1 as a prognosis-related long non-coding RNA (lncRNA) in melanoma.We further confirmed that FUT8-AS1 is downregulated in melanoma
Numerical investigation of flow characteristics over stepped spillways
Spillways are constructed to evacuate flood discharge safely so that a flood wave does not overtop the dam body.There are different types of spillways, with the ogee type being the conventional one.A stepped spillway is an example of a nonconventional spillway.The turbulent flow over a stepped spillway was Posture Board studied numerically by using